Speaker
Description
Introduction
Nuclear spin hyperpolarization (HP) enhances the NMR signal by several orders of magnitude by bringing the spins out of thermal equilibrium, populating one of the spin states in favor of the other. Enhanced spin polarization is especially advantageous at ultra-low magnetic field strengths, where thermal polarization may often result in NMR signal intensities that are indistinguishable from noise.
Among all nuclei, xenon-129 is a remarkable NMR probe as it is inert, soluble in biological tissues, and its hyperpolarization lifetime can last up to a few hours. Xenon-129 hyperpolarization is accomplished via spin-exchange optical pumping (SEOP), whereby spin order of a high-power laser is indirectly transferred to the
Previous works investigated the transfer of spin order from hyperpolarized
Methods
All measurements were performed on a lab-built NMR spectrometer operating in the 2 mT regime using a dual-resonance volume coil capable of simultaneously exciting and detecting
Results and Discussion
The SPINOE-enhanced
Conclusion
The NMR signal of thermally polarized nuclei is largely undetectable at ultra-low field strengths by standard induction techniques typically used at high field. Here we demonstrate a versatile method to continuously transfer the polarization of
References
[1] Song, Y.Q. (1999). Spin polarization-induced nuclear Overhauser effect: An application of spin-polarized xenon and helium. Concepts in Magnetic Resonance, 12(1), 6-20.
[2] Appelt, S., Häsing, F. W., Baer-Lang, S., Shah, N. J., & Blümich, B. (n.d.). Proton magnetization enhancement of solvents with hyperpolarized xenon in very low-magnetic fields. Chemical Physics Letters, 348, 263-269.
[3] Song, Y.Q., Goodson, B. M., Taylor, R. E., Laws, D. D., Navon, G., & Pines, A. (1997). Selective Enhancement of NMR Signals for α-Cyclodextrin with Laser-Polarized Xenon. Angewandte Chemie, 36(21), 2368-2370.